Claim and evidence Close ×
The 2023 Guidance recommends that manufacturers of benchtop nucleic acid synthesis equipment screen all customers purchasing such equipment to validate customer legitimacy, provide equipment only to customers with mechanisms to ensure that devices are operated by legitimate users, and integrate into the equipment the capability to screen sequences and to authenticate legitimate users. Copy claim link
Copy claim reference
Machine-checked, not reviewed by an editor Stated in source Supported
Supporting evidence: primary · 1 source
Provision Required action · provision ID us-hhs-screening-guidance-2023-benchtop-manufacturers Subject version As published in the Federal Register of 13 October 2023 (88 FR 70998) · Published 2023-10-13 · Effective date not established Date 2023-10-13 · publication Scope and limits States recommendations addressed to a category of manufacturer. It is not evidence that any manufacturer screens customers or has built such a capability into a device, and no technical means of doing so is recorded. Policy-level requirements only. The Guidance's accompanying recommendations on how such screening should be implemented, including its database and cryptographic passages, were read and excluded.
The evidence 02 primary source Supports the claim
Screening Framework Guidance for Providers and Users of Synthetic Nucleic Acids (88 FR 70998) ↗ Federal Register (Office of the Federal Register, National Archives) via govinfo.gov · Publication date unknown
Copy source reference
Cite the original source Cite the original document, not Selekoa. Check these details against it.
Copy APA
Download BibTeX Download RIS Download CSL-JSON
Source excerpt “Manufacturers should screen all Customers purchasing benchtop nucleic acid synthesizers to validate customer legitimacy and that the equipment is appropriate for their needs.” Location in source IV. Best practices for benchtop equipment, first bullet, 88 FR 71001
How it was read Retrieved directly from the publisher
Machine-checked · 2026-10-30
Source details and check notes Authors Federal Register (Office of the Federal Register, National Archives) via govinfo.gov Version Retrieved for the candidate pack on 2026-10-28 (SHA-256 20a3b9081d675539a0d8991d9021e5216ec373da9750df8711a4b55a47d54f16). Federal Register print of 13 October 2023, Vol. 88, No. 197, pp. 70998-71004, FR Doc. 2023-22540. The notice publishes the Guidance in full. Its technical sections (sequence screening methodology and the definitions that state screening criteria) were read but are not cited. Retrieved again at admission on 2026-10-30 (SHA-256 20a3b9081d675539a0d8991d9021e5216ec373da9750df8711a4b55a47d54f16, the same bytes). Canonical address Open the canonical source ↗ Accessed 2026-10-28 Language English (en) Attribution Federal Register (Office of the Federal Register, National Archives) via govinfo.gov, “Screening Framework Guidance for Providers and Users of Synthetic Nucleic Acids (88 FR 70998)”. Reuse No open redistribution licence asserted. Bibliographic metadata, editorial paraphrases and short attributed quotations (at most 50 words each). Recheck terms before wider redistribution. Check notes Candidate pack passage, AI and biosecurity (research/ai-bio). The quotation (23 words) matched the text retrieved for the candidate pack on 2026-10-28 and again at admission on 2026-10-30, in a fresh retrieval whose SHA-256 equals the pack’s. Matching ignored differences of whitespace, case, quotation marks, dashes and Unicode compatibility forms, so the source’s typography can differ. The next sentence adds that manufacturers should only provide synthesizers to customers that have mechanisms aimed at ensuring the devices are operated by legitimate users. No human editorial review. primary source Supports the claim
Screening Framework Guidance for Providers and Users of Synthetic Nucleic Acids (88 FR 70998) ↗ Federal Register (Office of the Federal Register, National Archives) via govinfo.gov · Publication date unknown
Copy source reference
Cite the original source Cite the original document, not Selekoa. Check these details against it.
Copy APA
Download BibTeX Download RIS Download CSL-JSON
Paraphrase manufacturers should integrate into benchtop nucleic acid synthesizers the capability to screen sequences and to authenticate legitimate users, at a level the Guidance describes as on a par with the screening practices it recommends for providers.
Location in source IV. Best practices for benchtop equipment, later bullet, 88 FR 71001
How it was read Retrieved directly from the publisher
Machine-checked · 2026-10-30
Source details and check notes Authors Federal Register (Office of the Federal Register, National Archives) via govinfo.gov Version Retrieved for the candidate pack on 2026-10-28 (SHA-256 20a3b9081d675539a0d8991d9021e5216ec373da9750df8711a4b55a47d54f16). Federal Register print of 13 October 2023, Vol. 88, No. 197, pp. 70998-71004, FR Doc. 2023-22540. The notice publishes the Guidance in full. Its technical sections (sequence screening methodology and the definitions that state screening criteria) were read but are not cited. Retrieved again at admission on 2026-10-30 (SHA-256 20a3b9081d675539a0d8991d9021e5216ec373da9750df8711a4b55a47d54f16, the same bytes). Canonical address Open the canonical source ↗ Accessed 2026-10-28 Language English (en) Attribution Federal Register (Office of the Federal Register, National Archives) via govinfo.gov, “Screening Framework Guidance for Providers and Users of Synthetic Nucleic Acids (88 FR 70998)”. Reuse No open redistribution licence asserted. Bibliographic metadata, editorial paraphrases and short attributed quotations (at most 50 words each). Recheck terms before wider redistribution. Check notes Candidate pack passage, AI and biosecurity (research/ai-bio). The paraphrase is Selekoa’s, written from the text retrieved for the candidate pack on 2026-10-28; it is not a quotation and was not machine-matched. Explicit paraphrase; the bullet's technical detail on databases and update frequency is excluded. No human editorial review. Status and meaning Editorial status. Not reviewed by an editor . An exploratory record that no editor has accepted. This status does not say whether a person has read any linked passage. Each evidence record above shows how it was checked.
Relation. An exact framework edition, or another document with an exact expression, states one provision: a capability threshold or risk level and its trigger, a required safeguard or action, a decision authority (who decides, recommends, can overrule or is informed), a stated exception, or another statement of its content, such as a licence term or a prospectus statement. The passage records what the document says, not implementation, compliance or effectiveness. Provisions with the same key align across editions of one family.
Date. Provision as the 2023 expression states it, dated by its publication. The 2010 guidance addressed providers of synthetic double-stranded DNA and not equipment manufacturers.
Record ID ab-scr-hhs-2023-benchtop-manufacturers