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The 2023 Guidance states that it pertains to the sale or transfer of all types of synthetic nucleic acids, DNA and RNA and single- or double-stranded, and that it sets recommended baseline standards for providers and for manufacturers of benchtop nucleic acid synthesis devices and best practices for customers, including institutions, principal users, end users and third-party vendors. Copy claim link
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Provision Threshold or trigger · provision ID us-hhs-screening-guidance-2023-scope Subject version As published in the Federal Register of 13 October 2023 (88 FR 70998) · Published 2023-10-13 · Effective date not established Date 2023-10-13 · publication Scope and limits States the Guidance's stated scope and addressees. Whether a named company falls in any category is not recorded, and a recommended baseline standard is not an obligation. The provision kind is `threshold`, the dataset’s kind for a provision that decides what is covered; the schema has no `definition` kind. The Guidance's definitions of the sequences subject to screening and its minimum screening length are technical screening criteria and are not recorded.
The evidence 02 primary source Supports the claim
Screening Framework Guidance for Providers and Users of Synthetic Nucleic Acids (88 FR 70998) ↗ Federal Register (Office of the Federal Register, National Archives) via govinfo.gov · Publication date unknown
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Source excerpt “The Guidance pertains to the sale or transfer of all types of synthetic nucleic acids, i.e., DNA and RNA, whether single- or double-stranded.” Location in source III. Goals and Scope of the Guidance, 88 FR 71000
How it was read Retrieved directly from the publisher
Machine-checked · 2026-10-30
Source details and check notes Authors Federal Register (Office of the Federal Register, National Archives) via govinfo.gov Version Retrieved for the candidate pack on 2026-10-28 (SHA-256 20a3b9081d675539a0d8991d9021e5216ec373da9750df8711a4b55a47d54f16). Federal Register print of 13 October 2023, Vol. 88, No. 197, pp. 70998-71004, FR Doc. 2023-22540. The notice publishes the Guidance in full. Its technical sections (sequence screening methodology and the definitions that state screening criteria) were read but are not cited. Retrieved again at admission on 2026-10-30 (SHA-256 20a3b9081d675539a0d8991d9021e5216ec373da9750df8711a4b55a47d54f16, the same bytes). Canonical address Open the canonical source ↗ Accessed 2026-10-28 Language English (en) Attribution Federal Register (Office of the Federal Register, National Archives) via govinfo.gov, “Screening Framework Guidance for Providers and Users of Synthetic Nucleic Acids (88 FR 70998)”. Reuse No open redistribution licence asserted. Bibliographic metadata, editorial paraphrases and short attributed quotations (at most 50 words each). Recheck terms before wider redistribution. Check notes Candidate pack passage, AI and biosecurity (research/ai-bio). The quotation (23 words) matched the text retrieved for the candidate pack on 2026-10-28 and again at admission on 2026-10-30, in a fresh retrieval whose SHA-256 equals the pack’s. Matching ignored differences of whitespace, case, quotation marks, dashes and Unicode compatibility forms, so the source’s typography can differ. No human editorial review. primary source Supports the claim
Screening Framework Guidance for Providers and Users of Synthetic Nucleic Acids (88 FR 70998) ↗ Federal Register (Office of the Federal Register, National Archives) via govinfo.gov · Publication date unknown
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Paraphrase the Guidance sets out recommended baseline standards for the nucleic acid synthesis industry (Providers) and for Manufacturers of benchtop nucleic acid synthesis devices, and best practices for Customers of synthetic nucleic acids, which it lists as institutions, Principal Users, End Users and Third-Party Vendors.
Location in source I. Introduction, 88 FR 70999-71000
How it was read Retrieved directly from the publisher
Machine-checked · 2026-10-30
Source details and check notes Authors Federal Register (Office of the Federal Register, National Archives) via govinfo.gov Version Retrieved for the candidate pack on 2026-10-28 (SHA-256 20a3b9081d675539a0d8991d9021e5216ec373da9750df8711a4b55a47d54f16). Federal Register print of 13 October 2023, Vol. 88, No. 197, pp. 70998-71004, FR Doc. 2023-22540. The notice publishes the Guidance in full. Its technical sections (sequence screening methodology and the definitions that state screening criteria) were read but are not cited. Retrieved again at admission on 2026-10-30 (SHA-256 20a3b9081d675539a0d8991d9021e5216ec373da9750df8711a4b55a47d54f16, the same bytes). Canonical address Open the canonical source ↗ Accessed 2026-10-28 Language English (en) Attribution Federal Register (Office of the Federal Register, National Archives) via govinfo.gov, “Screening Framework Guidance for Providers and Users of Synthetic Nucleic Acids (88 FR 70998)”. Reuse No open redistribution licence asserted. Bibliographic metadata, editorial paraphrases and short attributed quotations (at most 50 words each). Recheck terms before wider redistribution. Check notes Candidate pack passage, AI and biosecurity (research/ai-bio). The paraphrase is Selekoa’s, written from the text retrieved for the candidate pack on 2026-10-28; it is not a quotation and was not machine-matched. Explicit paraphrase; the sentence it paraphrases also names the category of sequences screened for, which is not reproduced. No human editorial review. Status and meaning Editorial status. Not reviewed by an editor . An exploratory record that no editor has accepted. This status does not say whether a person has read any linked passage. Each evidence record above shows how it was checked.
Relation. An exact framework edition, or another document with an exact expression, states one provision: a capability threshold or risk level and its trigger, a required safeguard or action, a decision authority (who decides, recommends, can overrule or is informed), a stated exception, or another statement of its content, such as a licence term or a prospectus statement. The passage records what the document says, not implementation, compliance or effectiveness. Provisions with the same key align across editions of one family.
Date. Provision as the 2023 expression states it, dated by its publication.
Record ID ab-scr-hhs-2023-scope