Claim · 1987-03-26 · publication · Stated in source · Supported

The Nature review "Knowledge-based prediction of protein structures and the design of novel molecules" (Blundell, Sibanda, Sternberg and Thornton, 26 March 1987) states that knowledge-based prediction techniques are of value in predicting receptor structures to aid the design of drugs.

One recorded claim. The claim panel gives its qualification, the source passages with their place in each source, and how it was checked.

What it connects

Knowledge-based prediction of protein structures and the design of novel molecules → articulates → Predicted protein structures aid drug design

Where it appears

AI in science →

Claim and evidence

Knowledge-based prediction of protein structures and the design of novel moleculesarticulates ↓Predicted protein structures aid drug design

Machine-checked, not reviewed by an editorStated in sourceSupported

Supporting evidence: primary · 1 source

Date: 1987-03-26 · publication Records dated 1987 →
Role: Earliest located
Register (kind of text): Nonfiction
Scope of the passage: Stated of knowledge-based (comparative) modelling, as a field of use; no drug is named.

Scope and limitsThe record documents what this text states, in its register; it is not evidence that the proposition is true and implies no influence on or from any other text. The method the abstract describes is knowledge-based modelling from analogies with known structures, not machine learning; the record bears on the AI period only as an earlier statement of the same expectation. Only the abstract was read. Earliest located for this proposition among the texts found by the searches described under “How we searched”; not a claim that no earlier text exists.

The evidence 02

primary sourceSupports the claim

Knowledge-based prediction of protein structures and the design of novel molecules

Nature · 1987-03-26

Cite the original source

Cite the original document, not Selekoa. Check these details against it.

Source excerpt

“Such techniques are of value in prediction of receptor structures to aid the design of drugs, herbicides or pesticides, antigens in vaccine design, and novel molecules in protein engineering.”

Location in source Abstract (article page)

How it was read Retrieved directly from the publisher

Machine-checked · 2026-10-30

Source details and check notes

Authors: T. L. Blundell; B. L. Sibanda; M. J. E. Sternberg; J. M. Thornton
Version: Retrieved for the candidate pack on 2026-10-30 (SHA-256 f57b0deefb38eab75e710ff7f8a64e9b53069ac5f53cdeb6338fa41621378bf9). Nature article page (review article); abstract and article metadata as served on 2026-10-30; full text behind subscription, not read. Its wording can change; earlier wording is not authenticated.
Canonical address: Open the canonical source ↗
Accessed: 2026-10-30
Language: English (en)
Attribution: T. L. Blundell, B. L. Sibanda, M. J. E. Sternberg, J. M. Thornton, “Knowledge-based prediction of protein structures and the design of novel molecules”, 1987-03-26.
Reuse: No open redistribution licence asserted. Bibliographic metadata, editorial paraphrases and short attributed quotations (at most 50 words each). Recheck terms before wider redistribution.
Check notes: Candidate pack passage, AI in biology (research/ai-in-biology). The quotation (29 words) matched the text retrieved for the candidate pack on 2026-10-30. Matching ignored differences of whitespace, case, quotation marks, dashes and Unicode compatibility forms, so the source’s typography can differ. The text is the primary source for its own statement. A cross-family machine check (2026-10-30, item A54) answered the record’s question blind from fresh retrievals and agreed with the record. No human editorial review.

primary sourceSupports the claim

Knowledge-based prediction of protein structures and the design of novel molecules

Nature · 1987-03-26

Cite the original source

Cite the original document, not Selekoa. Check these details against it.

Source excerpt

“Prediction of the tertiary structures of proteins may be carried out using a knowledge-based approach.”

Location in source Abstract (article page), what the techniques are

How it was read Retrieved directly from the publisher

Machine-checked · 2026-10-30

Source details and check notes

Authors: T. L. Blundell; B. L. Sibanda; M. J. E. Sternberg; J. M. Thornton
Version: Retrieved for the candidate pack on 2026-10-30 (SHA-256 f57b0deefb38eab75e710ff7f8a64e9b53069ac5f53cdeb6338fa41621378bf9). Nature article page (review article); abstract and article metadata as served on 2026-10-30; full text behind subscription, not read. Its wording can change; earlier wording is not authenticated.
Canonical address: Open the canonical source ↗
Accessed: 2026-10-30
Language: English (en)
Attribution: T. L. Blundell, B. L. Sibanda, M. J. E. Sternberg, J. M. Thornton, “Knowledge-based prediction of protein structures and the design of novel molecules”, 1987-03-26.
Reuse: No open redistribution licence asserted. Bibliographic metadata, editorial paraphrases and short attributed quotations (at most 50 words each). Recheck terms before wider redistribution.
Check notes: Candidate pack passage, AI in biology (research/ai-in-biology). The quotation (15 words) matched the text retrieved for the candidate pack on 2026-10-30. Matching ignored differences of whitespace, case, quotation marks, dashes and Unicode compatibility forms, so the source’s typography can differ. Shows that the predicted structures in question are computational predictions, not experimental structures. A cross-family machine check (2026-10-30, item A54) answered the record’s question blind from fresh retrievals and agreed with the record. No human editorial review.

Status and meaning

Editorial status. Not reviewed by an editor. An exploratory record that no editor has accepted. This status does not say whether a person has read any linked passage. Each evidence record above shows how it was checked.

Relation. A passage of the document meets the proposition’s criterion. The record documents what the text states, in its register (fiction and satire are labelled); it is not evidence that the proposition is true and implies no influence on or from another text.

Date. Publication and issue date printed on the Nature article page.

Record ID aib-arg-p1-blundell-1987