Claim · 1992 · publication · Stated in source · Supported

The Faraday Discussions paper "Modelling the structure and function of enzymes by machine learning" (Sternberg, Lewis, King and Muggleton, 1992) reports applying the machine-learning program GOLEM both to protein secondary-structure prediction and, separately, to modelling a structure-activity relationship in drug design.

One recorded claim. The claim panel gives its qualification, the source passages with their place in each source, and how it was checked.

What it connects

Modelling the structure and function of enzymes by machine learning → bears on → Predicted protein structures aid drug design

Where it appears

AI in science →

Claim and evidence

Modelling the structure and function of enzymes by machine learningbears on ↓Predicted protein structures aid drug design

Machine-checked, not reviewed by an editorStated in sourceSupported

Supporting evidence: primary · 1 source

Date: 1992 · publication Records dated 1992 →
Role: Context
Register (kind of text): Nonfiction
Missing element: Does not state that predicted protein structures aid drug design: the structure-prediction and drug-design applications are separate, and the drug-design model rests on ligand activities, not on a predicted protein structure.

Scope and limitsThe record documents what this text states, in its register; it is not evidence that the proposition is true and implies no influence on or from any other text. Read in the Europe PMC record of the abstract only. Kept as context because it is the earliest located text in these searches that joins machine learning, protein structure prediction and drug design in one study.

The evidence 01

primary sourceSupports the claim

Modelling the structure and function of enzymes by machine learning

Europe PMC (record of the PubMed abstract; article in Faraday Discussions) · 1992

Cite the original source

Cite the original document, not Selekoa. Check these details against it.

Source excerpt

“the prediction of protein secondary structure from sequence and (2) modelling a quantitative structure-activity relationship in drug design.”

Location in source Abstract (Europe PMC record, abstractText)

How it was read Retrieved directly from the publisher

Machine-checked · 2026-10-30

Source details and check notes

Authors: Sternberg MJ; Lewis RA; King RD; Muggleton S
Version: Retrieved for the candidate pack on 2026-10-30 (SHA-256 1611c4b9998ab817d0ca6ee50f96b66a460f7d26998e5ce1e86da7bb1f387790). Europe PMC REST core record (JSON) carrying the abstract as indexed in PubMed; the article itself was not retrieved.
Canonical address: Open the canonical source ↗
Accessed: 2026-10-30
Language: English (en)
Attribution: Sternberg MJ, Lewis RA, King RD, Muggleton S, “Modelling the structure and function of enzymes by machine learning”, 1992.
Reuse: No open redistribution licence asserted. Bibliographic metadata, editorial paraphrases and short attributed quotations (at most 50 words each). Recheck terms before wider redistribution.
Check notes: Candidate pack passage, AI in biology (research/ai-in-biology). The quotation (18 words) matched the text retrieved for the candidate pack on 2026-10-30. Matching ignored differences of whitespace, case, quotation marks, dashes and Unicode compatibility forms, so the source’s typography can differ. Abstract text relayed by Europe PMC's record of the PubMed abstract: the authors' own text, so primary; the journal expression was not read. The two applications are listed as separate problems. A cross-family machine check (2026-10-30, item B98) re-read the record’s sources and found full support. No human editorial review.

Status and meaning

Editorial status. Not reviewed by an editor. An exploratory record that no editor has accepted. This status does not say whether a person has read any linked passage. Each evidence record above shows how it was checked.

Relation. A passage of the document bears on the proposition without meeting its criterion; the record names the missing element. It is not an articulation and implies no influence.

Date. Year of the Faraday Discussions issue (vol. 93) as given by Europe PMC; no finer date was retrieved.

Record ID aib-arg-p1-sternberg-1992