Claim · 2021-07-15 · publication · Stated in source · Supported

Jumper et al. (Nature, 15 July 2021) state as a further limitation that AlphaFold is much weaker for proteins that have few intra-chain or homotypic contacts compared to the number of heterotypic contacts.

One recorded claim. The claim panel gives its qualification, the source passages with their place in each source, and how it was checked.

What it connects

Highly accurate protein structure prediction with AlphaFold (2021) → states provision → Stated limit: weaker for proteins with few intra-chain or homotypic contacts

Where it appears

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Claim and evidence

Highly accurate protein structure prediction with AlphaFold (2021)states provision ↓Stated limit: weaker for proteins with few intra-chain or homotypic contacts

Machine-checked, not reviewed by an editorStated in sourceSupported

Supporting evidence: primary · 1 source

Provision: Statement · provision ID mod-af2-heterotypic-limit
Date: 2021-07-15 · publication Records dated 2021 →

Scope and limitsThe authors' own observation about their system, referred by them to a companion paper that was not retrieved.

The evidence 01

primary sourceSupports the claim

Highly accurate protein structure prediction with AlphaFold

Nature · 2021-07-15

Archived copy, captured 2026-09-23: Highly accurate protein structure prediction with AlphaFold

Cite the original source

Cite the original document, not Selekoa. Check these details against it.

Source excerpt

“The other substantial limitation that we have observed is that AlphaFold is much weaker for proteins that have few intra-chain or homotypic contacts compared to the number of heterotypic contacts”

Location in source main text, discussion of limitations

How it was read Retrieved directly from the publisher

Machine-checked · 2026-10-30

Source details and check notes

Authors: John Jumper; Richard Evans; Alexander Pritzel; Tim Green; Michael Figurnov; Olaf Ronneberger; Kathryn Tunyasuvunakool; Russ Bates; Augustin Žídek; Anna Potapenko; Alex Bridgland; Clemens Meyer; Simon A. A. Kohl; Andrew J. Ballard; Andrew Cowie; Bernardino Romera-Paredes; Stanislav Nikolov; Rishub Jain; Jonas Adler; Trevor Back; Stig Petersen; David Reiman; Ellen Clancy; Michal Zielinski; Martin Steinegger; Michalina Pacholska; Tamas Berghammer; Sebastian Bodenstein; David Silver; Oriol Vinyals; Andrew W. Senior; Koray Kavukcuoglu; Pushmeet Kohli; Demis Hassabis
Version: Nature 596, 583–589 (2021), DOI 10.1038/s41586-021-03819-2; version of record HTML.
Canonical address: Open the canonical source ↗
Accessed: 2026-09-28
Language: English (en)
Archive copy: Open archived copy, captured 2026-09-23: Highly accurate protein structure prediction with AlphaFold. Captured 1896 days after the recorded publication date. An archive copy shows only what the archive retrieved on 2026-09-23. It does not prove what the page said earlier, and it can differ from the copy checked on 2026-09-28.
Attribution: John Jumper; Richard Evans; Alexander Pritzel; et al.. Highly accurate protein structure prediction with AlphaFold.
Reuse: No redistribution licence asserted.. Bibliographic metadata, editorial paraphrases and short attributed quotations (at most 50 words each). Recheck terms before wider redistribution.
Check notes: Candidate pack passage, AI in biology (research/ai-in-biology). The quotation (30 words) matched the text retrieved for the candidate pack on 2026-10-30. Matching ignored differences of whitespace, case, quotation marks, dashes and Unicode compatibility forms, so the source’s typography can differ. No human editorial review.

Status and meaning

Editorial status. Not reviewed by an editor. An exploratory record that no editor has accepted. This status does not say whether a person has read any linked passage. Each evidence record above shows how it was checked.

Relation. An exact framework edition, or another document with an exact expression, states one provision: a capability threshold or risk level and its trigger, a required safeguard or action, a decision authority (who decides, recommends, can overrule or is informed), a stated exception, or another statement of its content, such as a licence term or a prospectus statement. The passage records what the document says, not implementation, compliance or effectiveness. Provisions with the same key align across editions of one family.

Date. Date of the paper stating the limitation.

Record ID aib-mod-af2-heterotypic-limit