A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial
Nature Medicine 31, 2602–2610 (2025), published online 3 June 2025. The article page gives Received 19 December 2024, Accepted 25 April 2025, Published 3 June 2025, Issue date August 2025.
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- Authors credited
- No authorship claim recorded yet. The source record lists Zuojun Xu, Feng Ren, Ping Wang and Alex Zhavoronkov.
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- No date claim recorded yet. The source record gives the publication date as 2025-06-03.
- Exact source
- A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial Nature Medicine · published 2025-06-03 · Retrieved for the candidate pack on 2026-10-30 (SHA-256 ef9e787bc19076ee7fd0031e2edef34ff77b1f3796db7d7baa0e1ecefee66806). Nature Medicine article page, open access, version of record of 3 June 2025, as served on 2026-10-30. The author list is partial: it gives the authors the retrieved expression names and leaves out those it abbreviates.
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- A drug candidate discovered or designed with AI has entered human clinical trialsXu et al. (Nature Medicine, published online 3 June 2025) report a phase 2a randomized, placebo-controlled trial of rentosertib, which they describe as an AI-generated small-molecule inhibitor of a target discovered using generative AI.2025-06-03 · publication · Stated in source · Supported Inspect claim & evidence ↗A drug candidate discovered or designed with AI has entered human clinical trials: propositions page →
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- AI-discovered drug candidates succeed in clinical trials more often than historical averagesXu et al. (Nature Medicine, published online 3 June 2025) state that AI-discovered drugs have experienced similar levels of phase 2 failure as non-AI-discovered drugs, and that none has so far progressed through phase 3.2025-06-03 · publication · Stated in source · Supported Inspect claim & evidence ↗AI-discovered drug candidates succeed in clinical trials more often than historical averages: propositions page →
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