{"entities":[{"id":"aib-doc-esm3-release-2024","name":"ESM3: Simulating 500 million years of evolution with a language model","type":"document","subtype":"Press release","description":"EvolutionaryScale’s announcement of ESM3, dated 25 June 2024. The page as served in 2026 names an author the near-release capture does not show and carries an update of January 2025.","sourceIds":["source-aib-esm3-release-post","source-aib-esm3-release-capture"]},{"id":"aib-evolutionaryscale","name":"EvolutionaryScale","type":"organisation"},{"id":"aib-prop-biology-as-information-for-ai","name":"Biology is an information system that AI can read, describe or program","type":"concept","proposition":{"code":"P5","criterion":"The text states that biology is, or can be treated as, an information system, language or code, and that AI is, or may become, the means of reading, describing or programming it.","terms":["digital biology","programmable biology"],"withheld":[{"role":"earliest-located","reason":"Withheld until the criterion is decided (maintainer decision of 2026-10-30). The cross-family check located an earlier candidate, Searls (AAAI-88 proceedings, 1988), which treats genetic information as a knowledge representation for symbolic AI. Whether that meets the criterion’s AI clause is unsettled.","recordedAt":"2026-10-31"}]}},{"id":"aib-prop-ml-designs-new-proteins","name":"Machine-learning methods make proteins with new functions designable","type":"concept","proposition":{"code":"P4","criterion":"The text states that machine-learning models can be used, or will contribute, to designing proteins with functions, or sequences, not found among natural proteins.","terms":[],"withheld":[{"role":"earliest-located","reason":"Withheld until the criterion is decided (maintainer decision of 2026-10-30). The cross-family check located earlier candidates, Schneider and Wrede (1994) on sequence design assisted by neural networks and Greener, Moffat and Jones (arXiv, 26 June 2018) on sequences for a novel protein topology. Whether either meets the criterion’s “not found among natural proteins” is unsettled.","recordedAt":"2026-10-31"}]}}],"claims":[{"id":"aib-mod-esm3-open-model","subject":"aib-doc-esm3-release-2024","predicate":"states_provision","object":{"kind":"literal","value":"Weights and code for an ESM3 1.4B open model released under an MIT licence"},"topic":"ideas","statement":"EvolutionaryScale's ESM3 announcement states that it starts by releasing the weights and code for an ESM3 1.4B open model under an MIT license.","time":{"kind":"event","date":"2024-06-25","basis":"publication","note":"Date of the announcement. The quoted wording is attested only from the page as served on 2026-10-30; the cross-family check did not report it in the capture of 26 June 2024."},"resolution":"supported","evidenceIds":["evidence-aib-mod-esm3-open-model-1"],"attributes":{"provision":{"kind":"statement","key":"mod-esm3-open-model"}}},{"id":"aib-mod-esm3-release-published","subject":"aib-evolutionaryscale","predicate":"published","object":{"kind":"entity","entityId":"aib-doc-esm3-release-2024"},"topic":"institutions","statement":"EvolutionaryScale published its announcement of ESM3 on 25 June 2024.","time":{"kind":"event","date":"2024-06-25","basis":"publication","note":"Date of the post, 25 June 2024, as the page as served in 2026 (“6.25.24”) and its capture of 26 June 2024 (read by the cross-family check) both display it."},"derivation":"explicit","resolution":"supported","editorialState":"seed","evidenceIds":["evidence-aib-mod-esm3-release-published-1","evidence-aib-mod-esm3-release-published-2","evidence-aib-mod-esm3-release-published-3"]},{"id":"aib-mod-esm3-responsible-framework","subject":"aib-doc-esm3-release-2024","predicate":"states_provision","object":{"kind":"literal","value":"A responsible development framework stated to guide the company's work"},"topic":"ideas","statement":"EvolutionaryScale's ESM3 announcement states that the power and potential of these new technologies call for a commitment to principles of responsible development, including transparency and accountability, and that the company has crafted a responsible development framework to guide its progress.","time":{"kind":"event","date":"2024-06-25","basis":"publication","note":"Date of the announcement making the statement. The quoted wording is attested only from the page as served on 2026-10-30; the cross-family check did not report it in the capture of 26 June 2024."},"resolution":"supported","evidenceIds":["evidence-aib-mod-esm3-responsible-framework-1","evidence-aib-mod-esm3-responsible-framework-2"],"attributes":{"provision":{"kind":"statement","key":"mod-esm3-responsible-framework"}}},{"id":"aib-arg-p4-esm3-2024","subject":"aib-doc-esm3-release-2024","predicate":"articulates_proposition","object":{"kind":"entity","entityId":"aib-prop-ml-designs-new-proteins"},"topic":"ideas","statement":"EvolutionaryScale's ESM3 announcement (dated 25 June 2024) states that its language model generated a new fluorescent protein, esmGFP, with a sequence only 58% similar to the closest known fluorescent protein.","time":{"kind":"event","date":"2024-06-25","basis":"announcement","note":"Date printed on the post; the wording is attested in the copy served on 2026-10-30, which carries a January 2025 update notice."},"derivation":"explicit","resolution":"supported","editorialState":"seed","evidenceIds":["evidence-aib-arg-p4-esm3-2024-1","evidence-aib-arg-p4-esm3-2024-2"],"attributes":{"thought":{"roles":["articulation"],"register":"nonfiction","qualifier":"A company's statement of a sequence distant from known natural proteins with a known (fluorescent) function."}}},{"id":"aib-arg-p5-esm3-2024","subject":"aib-doc-esm3-release-2024","predicate":"articulates_proposition","object":{"kind":"entity","entityId":"aib-prop-biology-as-information-for-ai"},"topic":"ideas","statement":"EvolutionaryScale's ESM3 announcement (dated 25 June 2024) states that biology is written in a language not yet understood, and that learning to read and write in the code of life would make biology programmable.","time":{"kind":"event","date":"2024-06-25","basis":"announcement","note":"Date printed on the post; the wording is attested in the copy served on 2026-10-30."},"derivation":"explicit","resolution":"supported","editorialState":"seed","evidenceIds":["evidence-aib-arg-p5-esm3-2024-1","evidence-aib-arg-p5-esm3-2024-2"],"attributes":{"thought":{"roles":["articulation"],"register":"nonfiction","qualifier":"Conditional, in a company's announcement of its own model."}}}],"sources":[{"id":"source-aib-esm3-release-post","documentId":"aib-doc-esm3-release-2024","title":"ESM3: Simulating 500 million years of evolution with a language model","authors":["EvolutionaryScale"],"publisher":"EvolutionaryScale","publisherId":"aib-evolutionaryscale","publicationDate":"2024-06-25","version":"Retrieved for the candidate pack on 2026-10-30 (SHA-256 ba2099c4859e8a93fe926a43096fbf312f486e94352167322739329a812de489). Post dated 6.25.24 with a January 2025 update note, page as served on 2026-10-30. The page as served in 2026 carries a Tom Sercu byline that the capture of 26 June 2024 lacks; the cross-family check of 2026-10-30 found the date 25 June 2024 in that capture, without the byline, so the author is given as the company. Its wording can change; earlier wording is not authenticated.","evidenceUrl":"https://www.evolutionaryscale.ai/blog/esm3-release","language":"en"},{"id":"source-aib-esm3-release-capture","documentId":"aib-doc-esm3-release-2024","title":"ESM3: Simulating 500 million years of evolution with a language model","authors":["EvolutionaryScale"],"publisher":"EvolutionaryScale","publisherId":"aib-evolutionaryscale","publicationDate":"2024-06-25","version":"Internet Archive capture of 26 June 2024, opened by the cross-family machine check on 2026-10-30 (SHA-256 eae571fe7c016bdb1e9289c3bf480533ae17add4d4a58de63267cf8ef9e50ec5). The check reports the header date “June 25, 2024” and did not find the later byline. This admission could not reach the Internet Archive and did not repeat the reading.","evidenceUrl":"https://web.archive.org/web/20240626174011/https://www.evolutionaryscale.ai/blog/esm3-release","language":"en","archivedUrl":"https://web.archive.org/web/20240626174011/https://www.evolutionaryscale.ai/blog/esm3-release","archivedAt":"2024-06-26","accessedAt":"2026-10-30"}],"evidence":[{"id":"evidence-aib-mod-esm3-open-model-1","claimId":"aib-mod-esm3-open-model","sourceId":"source-aib-esm3-release-post","support":"supports","locator":"section \"Open Model\"","passage":"This starts with releasing the weights and code for an ESM3 1.4B open model under MIT license, to allow scientists and developers to build on the ideas and architecture of ESM3.","passageType":"quote"},{"id":"evidence-aib-mod-esm3-release-published-1","claimId":"aib-mod-esm3-release-published","sourceId":"source-aib-esm3-release-post","sourceRole":"primary","support":"supports","verification":"machine_checked","retrievalRoute":"direct"},{"id":"evidence-aib-mod-esm3-release-published-2","claimId":"aib-mod-esm3-release-published","sourceId":"source-aib-esm3-release-post","support":"supports","verification":"machine_checked","retrievalRoute":"direct"},{"id":"evidence-aib-mod-esm3-release-published-3","claimId":"aib-mod-esm3-release-published","sourceId":"source-aib-esm3-release-capture","support":"supports","verification":"machine_checked"},{"id":"evidence-aib-mod-esm3-responsible-framework-1","claimId":"aib-mod-esm3-responsible-framework","sourceId":"source-aib-esm3-release-post","support":"supports","locator":"section before \"ESM3: A frontier language model for biology\"","passage":"The power and potential of these new technologies call for a commitment to principles of responsible development, including transparency and accountability from the start.","passageType":"quote"},{"id":"evidence-aib-arg-p4-esm3-2024-1","claimId":"aib-arg-p4-esm3-2024","sourceId":"source-aib-esm3-release-post","sourceRole":"primary","support":"supports","verification":"machine_checked","retrievalRoute":"direct"},{"id":"evidence-aib-arg-p4-esm3-2024-2","claimId":"aib-arg-p4-esm3-2024","sourceId":"source-aib-esm3-release-post","support":"supports","verification":"machine_checked","retrievalRoute":"direct"},{"id":"evidence-aib-arg-p5-esm3-2024-1","claimId":"aib-arg-p5-esm3-2024","sourceId":"source-aib-esm3-release-post","sourceRole":"primary","support":"supports","verification":"machine_checked","retrievalRoute":"direct"},{"id":"evidence-aib-arg-p5-esm3-2024-2","claimId":"aib-arg-p5-esm3-2024","sourceId":"source-aib-esm3-release-post","support":"supports","verification":"machine_checked","retrievalRoute":"direct"}],"at":{"entities":[1344,1373,1440,1441],"claims":[3631,3632,3633,3736,3737],"sources":[1192,1207],"evidence":[5018,5019,5020,5021,5022,5185,5186,5187,5188]},"index":{"byClaim":[["aib-arg-p4-esm3-2024",["propositions:ai-in-science"]],["aib-arg-p5-esm3-2024",["propositions:ai-in-science"]]],"marks":[],"chronicle":{"years":[{"year":1863,"topics":{"ideas":5},"stated":0},{"year":1865,"topics":{"ideas":1},"stated":0},{"year":1872,"topics":{"ideas":7},"stated":0},{"year":1943,"topics":{"ideas":1},"stated":0},{"year":1947,"topics":{"ideas":2},"stated":0},{"year":1950,"topics":{"ideas":7},"stated":0},{"year":1951,"topics":{"ideas":5},"stated":0},{"year":1952,"topics":{"ideas":2},"stated":0},{"year":1955,"topics":{"ideas":31},"stated":0},{"year":1956,"topics":{"ideas":1},"stated":0},{"year":1957,"topics":{"ideas":1},"stated":0},{"year":1958,"topics":{"ideas":3},"stated":0},{"year":1959,"topics":{"ideas":6},"stated":0},{"year":1960,"topics":{"ideas":11},"stated":0},{"year":1961,"topics":{"ideas":10},"stated":0},{"year":1965,"topics":{"ideas":8},"stated":0},{"year":1966,"topics":{"ideas":20},"stated":0},{"year":1968,"topics":{"ideas":5},"stated":0},{"year":1969,"topics":{"ideas":2},"stated":0},{"year":1971,"topics":{"ideas":4},"stated":0},{"year":1972,"topics":{"ideas":1},"stated":0},{"year":1973,"topics":{"ideas":2},"stated":0},{"year":1974,"topics":{"ideas":2},"stated":0},{"year":1975,"topics":{"ideas":1},"stated":0},{"year":1976,"topics":{"ideas":1},"stated":0},{"year":1977,"topics":{"people":2,"ideas":8},"stated":0},{"year":1979,"topics":{"ideas":4},"stated":0},{"year":1980,"topics":{"ideas":2},"stated":0},{"year":1981,"topics":{"people":2},"stated":0},{"year":1982,"topics":{"ideas":4},"stated":0},{"year":1983,"topics":{"ideas":4},"stated":0},{"year":1984,"topics":{"ideas":21},"stated":0},{"year":1985,"topics":{"ideas":9},"stated":0},{"year":1986,"topics":{"ideas":18},"stated":0},{"year":1987,"topics":{"ideas":1},"stated":0},{"year":1988,"topics":{"ideas":6},"stated":0},{"year":1989,"topics":{"ideas":8},"stated":0},{"year":1990,"topics":{"ideas":5},"stated":0},{"year":1991,"topics":{"ideas":11},"stated":0},{"year":1992,"topics":{"ideas":9},"stated":0},{"year":1993,"topics":{"ideas":14,"people":3},"stated":0},{"year":1994,"topics":{"ideas":14},"stated":0},{"year":1995,"topics":{"ideas":10,"people":1},"stated":0},{"year":1996,"topics":{"ideas":71},"stated":0},{"year":1997,"topics":{"ideas":12},"stated":0},{"year":1998,"topics":{"ideas":49},"stated":0},{"year":1999,"topics":{"ideas":27,"people":1,"institutions":1},"stated":0},{"year":2000,"topics":{"ideas":62},"stated":0},{"year":2001,"topics":{"ideas":39},"stated":0},{"year":2002,"topics":{"ideas":30},"stated":0},{"year":2003,"topics":{"ideas":8},"stated":0},{"year":2004,"topics":{"ideas":12,"people":3},"stated":0},{"year":2005,"topics":{"ideas":10,"people":1},"stated":0},{"year":2006,"topics":{"ideas":26,"people":1},"stated":0},{"year":2007,"topics":{"ideas":20},"stated":0},{"year":2008,"topics":{"ideas":57,"people":3,"institutions":1},"stated":0},{"year":2009,"topics":{"ideas":10,"people":1},"stated":0},{"year":2010,"topics":{"people":3,"ideas":11,"institutions":1,"governance":4},"stated":0},{"year":2011,"topics":{"people":3,"ideas":7,"institutions":2},"stated":0},{"year":2012,"topics":{"people":4,"ideas":17,"institutions":2},"stated":0},{"year":2013,"topics":{"ideas":46,"people":4,"institutions":2,"capital":1},"stated":0},{"year":2014,"topics":{"institutions":2,"ideas":54,"people":5},"stated":0},{"year":2015,"topics":{"people":22,"ideas":122,"institutions":3,"capital":1},"stated":0},{"year":2016,"topics":{"ideas":88,"people":2},"stated":0},{"year":2017,"topics":{"people":16,"institutions":2,"ideas":128,"governance":2},"stated":0},{"year":2018,"topics":{"people":8,"ideas":158,"institutions":8,"governance":1},"stated":0},{"year":2019,"topics":{"capital":1,"compute":1,"people":10,"governance":19,"ideas":175,"institutions":4},"stated":0},{"year":2020,"topics":{"people":6,"ideas":98,"institutions":1,"governance":2},"stated":0},{"year":2021,"topics":{"people":27,"ideas":177,"compute":1,"institutions":23,"governance":4,"capital":6},"stated":0},{"year":2022,"topics":{"people":15,"ideas":217,"institutions":6,"governance":3,"compute":2,"capital":1},"stated":0},{"year":2023,"topics":{"capital":5,"compute":7,"institutions":23,"people":51,"governance":179,"ideas":389},"stated":0},{"year":2024,"topics":{"capital":12,"compute":19,"governance":282,"people":80,"ideas":178,"institutions":28},"stated":1},{"year":2025,"topics":{"governance":547,"compute":69,"capital":34,"people":90,"institutions":18,"ideas":178},"stated":7},{"year":2026,"topics":{"governance":442,"capital":8,"compute":32,"institutions":21,"ideas":91,"people":107},"stated":19},{"year":2027,"topics":{},"stated":9},{"year":2028,"topics":{},"stated":6},{"year":2029,"topics":{},"stated":3},{"year":2030,"topics":{},"stated":3},{"year":2032,"topics":{},"stated":2},{"year":2035,"topics":{},"stated":2},{"year":2039,"topics":{},"stated":1},{"year":2042,"topics":{},"stated":1},{"year":2050,"topics":{},"stated":1}],"scheduled":[],"statedBy":[]},"collections":[{"target":{"kind":"propositions","id":"superintelligence"},"title":"Propositions about superintelligence, 1863–2022","claimIds":[],"records":[]},{"target":{"kind":"propositions","id":"risk-debate"},"title":"Arguments about catastrophic risk from advanced AI","claimIds":[],"records":[]},{"target":{"kind":"propositions","id":"yudkowsky-arguments"},"title":"Eliezer Yudkowsky’s arguments on common claims about AI, 1996–2026","claimIds":[],"records":[]},{"target":{"kind":"propositions","id":"economics-of-machine-intelligence"},"title":"Economics of machine intelligence","claimIds":[],"records":[]},{"target":{"kind":"propositions","id":"orbital-compute-arguments"},"title":"Arguments about compute in orbit","claimIds":[],"records":[]},{"target":{"kind":"propositions","id":"ai-bio-arguments"},"title":"Arguments about AI and biological risk","claimIds":[],"records":[]},{"target":{"kind":"propositions","id":"ai-in-science"},"title":"AI in science","claimIds":["aib-arg-p4-esm3-2024","aib-arg-p5-esm3-2024"],"records":[]},{"target":{"kind":"documents"},"title":"Frontier safety frameworks","claimIds":[]},{"target":{"kind":"compare","id":"frontier-safety-frameworks"},"title":"Compare frameworks","claimIds":[]},{"target":{"kind":"control","id":"openai"},"title":"OpenAI’s control structure, 2015–2026","claimIds":[]},{"target":{"kind":"control","id":"anthropic"},"title":"Anthropic’s control structure, 2021–2026","claimIds":[]},{"target":{"kind":"commitments"},"title":"External commitments and obligations","claimIds":[]},{"target":{"kind":"question","id":"frameworks-to-obligations"},"title":"Frameworks, commitments and legal obligations, 2023–2026","claimIds":[]},{"target":{"kind":"reading"},"title":"Founding and early leadership","claimIds":[]}]},"version":"131evrz"}