{"entities":[{"id":"us-ostp-nucleic-acid-synthesis-screening-framework-2024","name":"Framework for Nucleic Acid Synthesis Screening","subtype":"Guidance","description":"The copy served from the Biden White House archive, marked 'Revised: September 2024' with '2024 Version 1: April 2024'. Release date 29 April 2024 from the HHS ASPR page, which also gives 'revised September 2024'; the cover of the retrieved copy carries 'Revised: September 2024' and '2024 Version 1: April 2024'. The day of the September 2024 revision is not stated and stays unknown. The framework's own effective date for the funding requirement, 26 April 2025, is recorded as a claim.","sourceIds":["source-ab-ostp-framework-2024"]},{"id":"us-ostp","name":"Office of Science and Technology Policy (Executive Office of the President)"}],"claims":[{"id":"ab-scr-ostp-framework-eo14110-link","statement":"The Framework for Nucleic Acid Synthesis Screening states that the committee that produced it was established in 2023 to develop a framework for nucleic acid synthesis screening pursuant to section 4.4(b)(i) of Executive Order 14110.","derivation":"explicit","resolution":"supported","editorialState":"seed","evidenceIds":["evidence-ab-scr-ostp-framework-eo14110-link-1"],"attributes":{"commitment":{"link":"responds_to"}}},{"id":"ab-scr-ostp-framework-published","statement":"The Office of Science and Technology Policy released the Framework for Nucleic Acid Synthesis Screening on 29 April 2024, and the copy served from the Biden White House archive on 28 October 2026 is marked as revised in September 2024, with April 2024 given as version 1.","derivation":"explicit","resolution":"supported","editorialState":"seed","evidenceIds":["evidence-ab-scr-ostp-framework-published-1","evidence-ab-scr-ostp-framework-published-2"]},{"id":"ab-scr-ostp-framework-2026-review","statement":"The Framework states that an interagency group designated by the Office of Science and Technology Policy will assess the scientific state of the art before 13 October 2026 and recommend any updates to the framework if necessary, and that such a group will consider and recommend updates every two years or as appropriate.","resolution":"supported","evidenceIds":["evidence-ab-scr-ostp-framework-2026-review-1","evidence-ab-scr-ostp-framework-2026-review-2"],"attributes":{"provision":{"kind":"required_action","key":"us-ostp-nucleic-acid-framework-review"}}},{"id":"ab-scr-ostp-framework-attestation","statement":"The Framework states that to adhere to it a provider or manufacturer should either post on a public webpage a statement self-attesting to following each of its criteria or give such a statement to the federally funded customer and the funding agency on request, and that the attestation should be signed by someone authorised for the organisation, give a point of contact, be updated by 1 January each year, and commit the organisation to notify customers and funding agencies within 72 hours if it ceases to adhere.","resolution":"supported","evidenceIds":["evidence-ab-scr-ostp-framework-attestation-1","evidence-ab-scr-ostp-framework-attestation-2"],"attributes":{"provision":{"kind":"required_action","key":"us-ostp-nucleic-acid-framework-attestation"}}},{"id":"ab-scr-ostp-framework-exceptions","statement":"The Framework states that the heads of federal funding agencies may issue exceptions to its requirements on a case-by-case basis where needed to address health or national security priorities, in consultation with the Director of the Office of Science and Technology Policy and the Federal Bureau of Investigation.","resolution":"supported","evidenceIds":["evidence-ab-scr-ostp-framework-exceptions-1"],"attributes":{"provision":{"kind":"exception","key":"us-ostp-nucleic-acid-framework-agency-exceptions"}}},{"id":"ab-scr-ostp-framework-scope","statement":"The Framework states that it applies to federally funded life sciences research involving the procurement of all types of synthetic nucleic acids that contain a synthetic sequence within the category the framework defines, and of any benchtop equipment capable of synthesising nucleic acids, and to distribution by providers including biofoundries, cloud laboratories, institutions with core synthesis facilities and contract research organisations, and by manufacturers of benchtop equipment.","resolution":"supported","evidenceIds":["evidence-ab-scr-ostp-framework-scope-1","evidence-ab-scr-ostp-framework-scope-2"],"attributes":{"provision":{"kind":"threshold","key":"us-ostp-nucleic-acid-framework-scope"}}},{"id":"ab-scr-ostp-framework-funding-requirement-effective","statement":"The Framework states that the requirement that procurement for federally funded research be conducted through providers or manufacturers that adhere to the framework takes effect for all purchases of synthetic nucleic acids and benchtop nucleic acid synthesis equipment that take place on or after 26 April 2025.","resolution":"supported","evidenceIds":["evidence-ab-scr-ostp-framework-funding-requirement-effective-1","evidence-ab-scr-ostp-framework-funding-requirement-effective-2"],"attributes":{"provision":{"kind":"date","key":"ostp-framework-funding-requirement-effective"}}}],"sources":[{"id":"source-ab-ostp-framework-2024","title":"Framework for Nucleic Acid Synthesis Screening (National Science and Technology Council, Fast Track Action Committee on Synthetic Nucleic Acid Procurement Screening)","authors":["Office of Science and Technology Policy, Executive Office of the President (copy served from the Biden White House archive)"],"publisher":"Office of Science and Technology Policy, Executive Office of the President (copy served from the Biden White House archive)","publicationDate":null,"version":"Retrieved for the candidate pack on 2026-10-28 (SHA-256 3b083af856f92dfa91bbf5de344ca81761a4eb4c3a0323fa390e37330a802715). The copy linked from the HHS ASPR page on 2026-10-28, marked on its cover 'Revised: September 2024' with '2024 Version 1: April 2024'. The April 2024 version 1 was not retrieved. Technical passages (screening windows, matching methods, the criteria that may inform which sequences are in scope) were read but are not cited. Retrieved again at admission on 2026-10-30 (SHA-256 3b083af856f92dfa91bbf5de344ca81761a4eb4c3a0323fa390e37330a802715, the same bytes).","evidenceUrl":"https://bidenwhitehouse.archives.gov/wp-content/uploads/2024/04/Nucleic-Acid_Synthesis_Screening_Framework.pdf","language":"en"}],"evidence":[{"id":"evidence-ab-scr-ostp-framework-eo14110-link-1","sourceRole":"primary","support":"supports","verification":"machine_checked","retrievalRoute":"direct"},{"id":"evidence-ab-scr-ostp-framework-published-1","sourceRole":"primary","support":"supports","verification":"machine_checked","retrievalRoute":"direct"},{"id":"evidence-ab-scr-ostp-framework-published-2","support":"supports","verification":"machine_checked","retrievalRoute":"direct"},{"id":"evidence-ab-scr-ostp-framework-2026-review-1","support":"supports","locator":"V. Screening Framework, criterion 2, PDF p. 11 (printed p. 10)","passage":"an OSTP-designated interagency group will assess the scientific state of the art before October 13, 2026 and recommend any updates to this framework if necessary","passageType":"quote"},{"id":"evidence-ab-scr-ostp-framework-attestation-1","support":"supports","locator":"V. Screening Framework, criterion 1, p. 8","passage":"either post on a public webpage a statement that self-attests to following each of the criteria in this framework, or provide such a statement to the federally funded customer and the federal funding agency upon request","passageType":"quote"},{"id":"evidence-ab-scr-ostp-framework-exceptions-1","support":"supports","locator":"II. Role of Federal Funding Agencies, p. 5","passage":"The heads of federal funding agencies may issue exceptions to the requirements in this framework on a case-by-case basis when needed to address health or national security priorities, in consultation with the Director of OSTP and the Federal Bureau of Investigation.","passageType":"quote"},{"id":"evidence-ab-scr-ostp-framework-scope-1","support":"supports","locator":"III. Scope, p. 5","passage":"This framework applies to federally funded life sciences research involving the procurement of all types of synthetic nucleic acids","passageType":"quote"},{"id":"evidence-ab-scr-ostp-framework-funding-requirement-effective-1","support":"supports","locator":"II. Role of Federal Funding Agencies, p. 5","passage":"This requirement will take effect for all purchases of synthetic nucleic acids and benchtop nucleic synthesis equipment that take place on or after April 26, 2025.","passageType":"quote"}],"at":{"entities":[1219,1226],"claims":[3302,3303,3304,3305,3306,3307,3315],"sources":[1047],"evidence":[4529,4530,4531,4532,4534,4536,4537,4549]},"version":"1lg47t7"}