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EvolutionaryScale's ESM3 announcement (dated 25 June 2024) states that its language model generated a new fluorescent protein, esmGFP, with a sequence only 58% similar to the closest known fluorescent protein. Copy claim link
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Machine-checked, not reviewed by an editor Stated in source Supported
Supporting evidence: primary · 1 source
Date 2024-06-25 · announcement Records dated 2024 → Role Articulation Register (kind of text) Nonfiction Scope of the passage A company's statement of a sequence distant from known natural proteins with a known (fluorescent) function. Scope and limits The record documents what this text states, in its register; it is not evidence that the proposition is true and implies no influence on or from any other text. A company's statement about its own model; the estimate that the result is "equivalent to simulating over 500 million years of evolution" is the company's. The post describes generation and screening steps; only its summary statements are cited.
The evidence 02 primary source Supports the claim
ESM3: Simulating 500 million years of evolution with a language model ↗ EvolutionaryScale · 2024-06-25
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Source excerpt “esmGFP, our new protein, has a sequence that is only 58% similar to the closest known fluorescent protein.” Location in source Section on generating a new fluorescent protein
How it was read Retrieved directly from the publisher
Machine-checked · 2026-10-30
Source details and check notes Authors EvolutionaryScale Version Retrieved for the candidate pack on 2026-10-30 (SHA-256 ba2099c4859e8a93fe926a43096fbf312f486e94352167322739329a812de489). Post dated 6.25.24 with a January 2025 update note, page as served on 2026-10-30. The page as served in 2026 carries a Tom Sercu byline that the capture of 26 June 2024 lacks; the cross-family check of 2026-10-30 found the date 25 June 2024 in that capture, without the byline, so the author is given as the company. Its wording can change; earlier wording is not authenticated. Canonical address Open the canonical source ↗ Accessed 2026-10-30 Language English (en) Attribution EvolutionaryScale, “ESM3: Simulating 500 million years of evolution with a language model”, 2024-06-25. Reuse No open redistribution licence asserted. Bibliographic metadata, editorial paraphrases and short attributed quotations (at most 50 words each). Recheck terms before wider redistribution. Check notes Candidate pack passage, AI in biology (research/ai-in-biology). The quotation (18 words) matched the text retrieved for the candidate pack on 2026-10-30. Matching ignored differences of whitespace, case, quotation marks, dashes and Unicode compatibility forms, so the source’s typography can differ. The company is the primary source for its own statement. A cross-family machine check (2026-10-30, item B114) re-read the record’s sources and found full support. No human editorial review. primary source Supports the claim
ESM3: Simulating 500 million years of evolution with a language model ↗ EvolutionaryScale · 2024-06-25
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Cite the original source Cite the original document, not Selekoa. Check these details against it.
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Source excerpt “we estimate that this generation of a new fluorescent protein is equivalent to simulating over 500 million years of evolution.” Location in source Same section
How it was read Retrieved directly from the publisher
Machine-checked · 2026-10-30
Source details and check notes Authors EvolutionaryScale Version Retrieved for the candidate pack on 2026-10-30 (SHA-256 ba2099c4859e8a93fe926a43096fbf312f486e94352167322739329a812de489). Post dated 6.25.24 with a January 2025 update note, page as served on 2026-10-30. The page as served in 2026 carries a Tom Sercu byline that the capture of 26 June 2024 lacks; the cross-family check of 2026-10-30 found the date 25 June 2024 in that capture, without the byline, so the author is given as the company. Its wording can change; earlier wording is not authenticated. Canonical address Open the canonical source ↗ Accessed 2026-10-30 Language English (en) Attribution EvolutionaryScale, “ESM3: Simulating 500 million years of evolution with a language model”, 2024-06-25. Reuse No open redistribution licence asserted. Bibliographic metadata, editorial paraphrases and short attributed quotations (at most 50 words each). Recheck terms before wider redistribution. Check notes Candidate pack passage, AI in biology (research/ai-in-biology). The quotation (20 words) matched the text retrieved for the candidate pack on 2026-10-30. Matching ignored differences of whitespace, case, quotation marks, dashes and Unicode compatibility forms, so the source’s typography can differ. The company's own estimate, attributed. A cross-family machine check (2026-10-30, item B114) re-read the record’s sources and found full support. No human editorial review. Status and meaning Editorial status. Not reviewed by an editor . An exploratory record that no editor has accepted. This status does not say whether a person has read any linked passage. Each evidence record above shows how it was checked.
Relation. A passage of the document meets the proposition’s criterion. The record documents what the text states, in its register (fiction and satire are labelled); it is not evidence that the proposition is true and implies no influence on or from another text.
Date. Date printed on the post; the wording is attested in the copy served on 2026-10-30, which carries a January 2025 update notice.
Record ID aib-arg-p4-esm3-2024