ESM3: Simulating 500 million years of evolution with a language model
EvolutionaryScale’s announcement of ESM3, dated 25 June 2024. The page as served in 2026 names an author the near-release capture does not show and carries an update of January 2025.
- Issued by
- EvolutionaryScale
- Authors credited
- No authorship claim recorded yet. The source records list EvolutionaryScale.
- Dates
- Published 2024-06-25 issue evidence
- Exact source
- ESM3: Simulating 500 million years of evolution with a language model EvolutionaryScale · published 2024-06-25 · Internet Archive capture of 26 June 2024, opened by the cross-family machine check on 2026-10-30 (SHA-256 eae571fe7c016bdb1e9289c3bf480533ae17add4d4a58de63267cf8ef9e50ec5). The check reports the header date “June 25, 2024” and did not find the later byline. This admission could not reach the Internet Archive and did not repeat the reading.Archived copy, captured 2024-06-26: ESM3: Simulating 500 million years of evolution with a language model. Captured 1 day after the recorded publication date. An archive copy shows only what the archive retrieved on 2024-06-26. It does not prove what the page said earlier, and it can differ from the copy checked on 2026-10-30.
- ESM3: Simulating 500 million years of evolution with a language model EvolutionaryScale · published 2024-06-25 · Retrieved for the candidate pack on 2026-10-30 (SHA-256 ba2099c4859e8a93fe926a43096fbf312f486e94352167322739329a812de489). Post dated 6.25.24 with a January 2025 update note, page as served on 2026-10-30. The page as served in 2026 carries a Tom Sercu byline that the capture of 26 June 2024 lacks; the cross-family check of 2026-10-30 found the date 25 June 2024 in that capture, without the byline, so the author is given as the company. Its wording can change; earlier wording is not authenticated.
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- AI in science →2 records on this document
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Articulates · 2
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- Machine-learning methods make proteins with new functions designableEvolutionaryScale's ESM3 announcement (dated 25 June 2024) states that its language model generated a new fluorescent protein, esmGFP, with a sequence only 58% similar to the closest known fluorescent protein.2024-06-25 · announcement · Stated in source · Supported Inspect claim & evidence ↗Machine-learning methods make proteins with new functions designable: propositions page →
- Biology is an information system that AI can read, describe or programEvolutionaryScale's ESM3 announcement (dated 25 June 2024) states that biology is written in a language not yet understood, and that learning to read and write in the code of life would make biology programmable.2024-06-25 · announcement · Stated in source · Supported Inspect claim & evidence ↗Biology is an information system that AI can read, describe or program: propositions page →
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What the document states
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- StatementWeights and code for an ESM3 1.4B open model released under an MIT licence“This starts with releasing the weights and code for an ESM3 1.4B open model under MIT license, to allow scientists and developers to build on the ideas and architecture of ESM3.”section "Open Model"Inspect claim & evidence ↗
- StatementA responsible development framework stated to guide the company's work“The power and potential of these new technologies call for a commitment to principles of responsible development, including transparency and accountability from the start.”section before "ESM3: A frontier language model for biology"Inspect claim & evidence ↗