Claim · 2023-09-19 · publication · Stated in source · Supported

Cheng et al. (Science, 22 September 2023) state that they provide, as a resource to the community, a database of predictions for all possible human single amino acid substitutions and classify 89% of missense variants as either likely benign or likely pathogenic.

One recorded claim. The claim panel gives its qualification, the source passages with their place in each source, and how it was checked.

What it connects

Accurate proteome-wide missense variant effect prediction with AlphaMissense → states provision → Database of predictions classifying 89% of missense variants

Where it appears

No collection page holds this claim. It is listed with its records in the explorer.

Claim and evidence

Accurate proteome-wide missense variant effect prediction with AlphaMissensestates provision ↓Database of predictions classifying 89% of missense variants

Machine-checked, not reviewed by an editorStated in sourceSupported

Supporting evidence: primary · 1 source; Context: primary · 1 source

Provision: Statement · provision ID mod-alphamissense-database
Date: 2023-09-19 · publication Records dated 2023 →

Scope and limitsThe authors' own statement about their resource and their classification rate; it is a model output and not a clinical determination. Read in the PubMed-reproduced abstract only.

The evidence 02

primary sourceSupports the claim

Accurate proteome-wide missense variant effect prediction with AlphaMissense (PubMed record)

National Library of Medicine (PubMed), reproducing the Science abstract · 2023-09-22

Cite the original source

Cite the original document, not Selekoa. Check these details against it.

Source excerpt

“we provide a database of predictions for all possible human single amino acid substitutions and classify 89% of missense variants as either likely benign or likely pathogenic”

Location in source abstract as reproduced in the PubMed record

How it was read Retrieved directly from the publisher

Machine-checked · 2026-10-30

Source details and check notes

Authors: Jun Cheng; Guido Novati; Joshua Pan; Clare Bycroft; Akvilė Žemgulytė; Taylor Applebaum; Alexander Pritzel; Lai Hong Wong; Michal Zielinski; Tobias Sargeant; Rosalia G. Schneider; Andrew W. Senior; John Jumper; Demis Hassabis; Pushmeet Kohli; Žiga Avsec
Version: Retrieved for the candidate pack on 2026-10-30 (SHA-256 b4d0620c740eba59d1ef270139d846ed23928b3555ffd393f1f82903276e0cf8). PubMed record 37733863 as served on 2026-10-30, carrying the abstract, author list and dates of Science 381(6664):eadg7492; science.org refuses direct retrieval and no PMC copy exists. The publisher’s page, in a capture read by the cross-family check of 2026-10-30, gives online publication on 19 September 2023 and print on 22 September 2023; PubMed labels 22 September as the electronic date. The disagreement is kept. Its wording can change; earlier wording is not authenticated.
Canonical address: Open the canonical source ↗
Accessed: 2026-10-30
Language: English (en)
Attribution: Jun Cheng, Guido Novati, Joshua Pan, Clare Bycroft, Akvilė Žemgulytė, Taylor Applebaum, Alexander Pritzel, Lai Hong Wong, Michal Zielinski, Tobias Sargeant, Rosalia G. Schneider, Andrew W. Senior, John Jumper, Demis Hassabis, Pushmeet Kohli, Žiga Avsec, “Accurate proteome-wide missense variant effect prediction with AlphaMissense (PubMed record)”, 2023-09-22.
Reuse: No open redistribution licence asserted. Bibliographic metadata, editorial paraphrases and short attributed quotations (at most 50 words each). Recheck terms before wider redistribution.
Check notes: Candidate pack passage, AI in biology (research/ai-in-biology). The quotation (27 words) matched the text retrieved for the candidate pack on 2026-10-30. Matching ignored differences of whitespace, case, quotation marks, dashes and Unicode compatibility forms, so the source’s typography can differ. Abstract text relayed by the PubMed record (PMID 37733863): the authors' own text, so primary; the journal expression was not read. No human editorial review.

primary sourceContext only

Accurate proteome-wide missense variant effect prediction with AlphaMissense

Science (American Association for the Advancement of Science) · 2023-09-19

Archived copy, captured 2023-09-22: Accurate proteome-wide missense variant effect prediction with AlphaMissense

Cite the original source

Cite the original document, not Selekoa. Check these details against it.

Paraphrase

The publisher’s page gives online publication on 19 September 2023 and print publication on 22 September 2023, and lists the authors.

Location in source Publication history of the captured article page

Machine-checked · 2026-10-30

Source details and check notes

Authors: Jun Cheng; Guido Novati; Joshua Pan; Clare Bycroft; Akvilė Žemgulytė; Taylor Applebaum; Alexander Pritzel; Lai Hong Wong; Michal Zielinski; Tobias Sargeant; Rosalia G. Schneider; Andrew W. Senior; John Jumper; Demis Hassabis; Pushmeet Kohli; Žiga Avsec
Version: Internet Archive capture of 22 September 2023 of the publisher’s article page, opened by the cross-family machine check on 2026-10-30 (SHA-256 542aa040aa681270737a933f74fb566c33a265b63fea040d0e58dbd72690f609). The check reports the author list and a publication history of online publication on 19 September 2023 and print on 22 September 2023. This admission could not reach the Internet Archive and did not repeat the reading.
Canonical address: Open the canonical source ↗
Accessed: 2026-10-30
Language: English (en)
Archive copy: Open archived copy, captured 2023-09-22: Accurate proteome-wide missense variant effect prediction with AlphaMissense. Captured 3 days after the recorded publication date. An archive copy shows only what the archive retrieved on 2023-09-22. It does not prove what the page said earlier, and it can differ from the copy checked on 2026-10-30.
Attribution: Jun Cheng, Guido Novati, Joshua Pan, Clare Bycroft, Akvilė Žemgulytė, Taylor Applebaum, Alexander Pritzel, Lai Hong Wong, Michal Zielinski, Tobias Sargeant, Rosalia G. Schneider, Andrew W. Senior, John Jumper, Demis Hassabis, Pushmeet Kohli, Žiga Avsec, “Accurate proteome-wide missense variant effect prediction with AlphaMissense”, 2023-09-19.
Reuse: No open redistribution licence asserted. Bibliographic metadata, editorial paraphrases and short attributed quotations (at most 50 words each). Recheck terms before wider redistribution.
Check notes: Added at the admission of the AI in biology pack (research/ai-in-biology). The cross-family machine check of 2026-10-30 opened the Internet Archive capture this source names; this admission could not reach the Internet Archive and did not repeat the reading. The passage is Selekoa’s paraphrase of what the check reported, not a quotation. No human editorial review.

Status and meaning

Editorial status. Not reviewed by an editor. An exploratory record that no editor has accepted. This status does not say whether a person has read any linked passage. Each evidence record above shows how it was checked.

Relation. An exact framework edition, or another document with an exact expression, states one provision: a capability threshold or risk level and its trigger, a required safeguard or action, a decision authority (who decides, recommends, can overrule or is informed), a stated exception, or another statement of its content, such as a licence term or a prospectus statement. The passage records what the document says, not implementation, compliance or effectiveness. Provisions with the same key align across editions of one family.

Date. Online publication date on the publisher’s page, in its capture of 22 September 2023 read by the cross-family machine check of 2026-10-30; the print issue is dated 22 September 2023, which the PubMed record cited here labels as the date of electronic publication. The two expressions disagree, and the disagreement is kept.

Record ID aib-mod-alphamissense-database