Accurate proteome-wide missense variant effect prediction with AlphaMissense
Science 381(6664), eadg7492. The publisher’s page gives online publication on 19 September 2023 and print on 22 September 2023; the PubMed record labels 22 September as the electronic date. The disagreement is kept.
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- Authors credited
- Demis Hassabis · John Jumper · Pushmeet Kohli · Andrew W. Senior
- Dates
- Published 2023-09-19 authorship evidence authorship evidence authorship evidence authorship evidence
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- Accurate proteome-wide missense variant effect prediction with AlphaMissense (PubMed record) National Library of Medicine (PubMed), reproducing the Science abstract · published 2023-09-22 · Retrieved for the candidate pack on 2026-10-30 (SHA-256 b4d0620c740eba59d1ef270139d846ed23928b3555ffd393f1f82903276e0cf8). PubMed record 37733863 as served on 2026-10-30, carrying the abstract, author list and dates of Science 381(6664):eadg7492; science.org refuses direct retrieval and no PMC copy exists. The publisher’s page, in a capture read by the cross-family check of 2026-10-30, gives online publication on 19 September 2023 and print on 22 September 2023; PubMed labels 22 September as the electronic date. The disagreement is kept. Its wording can change; earlier wording is not authenticated.
- Accurate proteome-wide missense variant effect prediction with AlphaMissense Science (American Association for the Advancement of Science) · published 2023-09-19 · Internet Archive capture of 22 September 2023 of the publisher’s article page, opened by the cross-family machine check on 2026-10-30 (SHA-256 542aa040aa681270737a933f74fb566c33a265b63fea040d0e58dbd72690f609). The check reports the author list and a publication history of online publication on 19 September 2023 and print on 22 September 2023. This admission could not reach the Internet Archive and did not repeat the reading.Archived copy, captured 2023-09-22: Accurate proteome-wide missense variant effect prediction with AlphaMissense. Captured 3 days after the recorded publication date. An archive copy shows only what the archive retrieved on 2023-09-22. It does not prove what the page said earlier, and it can differ from the copy checked on 2026-10-30.
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Issue and authorship records
- Author: Demis HassabisDemis Hassabis is credited as a co-author of Cheng et al., ‘Accurate proteome-wide missense variant effect prediction with AlphaMissense’ (Science, 2023), according to its PubMed record.2023-09-19 · publication · Stated in source · Supported Rests on reportingInspect claim & evidence ↗Demis Hassabis: person page →
- Author: John JumperJohn Jumper is credited as a co-author of Cheng et al., ‘Accurate proteome-wide missense variant effect prediction with AlphaMissense’ (Science, 2023), according to its PubMed record.2023-09-19 · publication · Stated in source · Supported Rests on reportingInspect claim & evidence ↗John Jumper: person page →
- Author: Pushmeet KohliPushmeet Kohli is credited as a co-author of Cheng et al., ‘Accurate proteome-wide missense variant effect prediction with AlphaMissense’ (Science, 2023), according to its PubMed record.2023-09-19 · publication · Stated in source · Supported Rests on reportingInspect claim & evidence ↗Pushmeet Kohli: person page →
- Author: Andrew W. SeniorAndrew W. Senior is credited as a co-author of Cheng et al., ‘Accurate proteome-wide missense variant effect prediction with AlphaMissense’ (Science, 2023), according to its PubMed record.2023-09-19 · publication · Stated in source · Supported Rests on reportingInspect claim & evidence ↗Andrew W. Senior: person page →
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- StatementAlphaMissense described as an adaptation of AlphaFold for missense variant pathogenicity“We present AlphaMissense, an adaptation of AlphaFold fine-tuned on human and primate variant population frequency databases to predict missense variant pathogenicity.”abstract as reproduced in the PubMed recordInspect claim & evidence ↗
- StatementDatabase of predictions classifying 89% of missense variants“we provide a database of predictions for all possible human single amino acid substitutions and classify 89% of missense variants as either likely benign or likely pathogenic”abstract as reproduced in the PubMed recordInspect claim & evidence ↗