Accurate structure prediction of biomolecular interactions with AlphaFold 3
Nature 630, 493–500, published online 8 May 2024. Dates from the article page, "About this article": "Received: 19 December 2023 Accepted: 29 April 2024 Published: 08 May 2024 Version of record: 11 June 2024 Issue date: 13 June 2024". The page also states that an addendum was published on 27 November 2024.
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- Josh Abramson · Demis Hassabis · John Jumper · Pushmeet Kohli
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- Published 2024-05-08 authorship evidence authorship evidence authorship evidence authorship evidence
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- Accurate structure prediction of biomolecular interactions with AlphaFold 3 Nature · published 2024-05-08 · Retrieved for the candidate pack on 2026-10-30 (SHA-256 6b48f4d09ceeaa4fceb473e37dbc7789b2a5e57633ca7b200aaa4646e4eac657). Nature article page (open access), as served on 2026-10-30 (the page notes an addendum of 27 November 2024); author list and Author information section. The candidate pack retrieved the same page a second time on 2026-10-30, at an address carrying a cookie-error query string (SHA-256 40b72aa72d12e37e9b6df5a3ebad23bfcb68a9c2c4db79a7df9b2ad76231b1c3); the passages read in that retrieval are cited here.
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- Author: Josh AbramsonJosh Abramson is credited as the lead-listed author of ‘Accurate structure prediction of biomolecular interactions with AlphaFold 3’ (Nature, published online 8 May 2024), one of eight authors the paper says contributed equally.2024-05-08 · publication · Stated in source · Supported Inspect claim & evidence ↗Josh Abramson: person page →
- Author: Demis HassabisDemis Hassabis is credited as a co-author of Abramson et al., ‘Accurate structure prediction of biomolecular interactions with AlphaFold 3’ (Nature, published online 8 May 2024), and is one of five authors the paper says jointly supervised the work.2024-05-08 · publication · Stated in source · Supported Inspect claim & evidence ↗Demis Hassabis: person page →
- Author: John JumperJohn M. Jumper is credited as a co-author of Abramson et al., ‘Accurate structure prediction of biomolecular interactions with AlphaFold 3’ (Nature, published online 8 May 2024), and is one of five authors the paper says jointly supervised the work.2024-05-08 · publication · Stated in source · Supported Inspect claim & evidence ↗John Jumper: person page →
- Author: Pushmeet KohliPushmeet Kohli is credited as a co-author of Abramson et al., ‘Accurate structure prediction of biomolecular interactions with AlphaFold 3’ (Nature, published online 8 May 2024), and is one of five authors the paper says jointly supervised the work.2024-05-08 · publication · Stated in source · Supported Inspect claim & evidence ↗Pushmeet Kohli: person page →
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- StatementAccuracy compared with specialised tools, as the authors state it“far greater accuracy for protein-ligand interactions compared with state-of-the-art docking tools, much higher accuracy for protein-nucleic acid interactions compared with nucleic-acid-specific predictors and substantially higher antibody-antigen prediction accuracy”abstractInspect claim & evidence ↗
- StatementStated limit: chirality violations at a rate of 4.4% in the benchmark“Despite this, we still observe a chirality violation rate of 4.4% in the benchmark.”"Model limitations" sectionInspect claim & evidence ↗
- StatementCode availability as printed on the article page served on 2026-10-30: non-commercial server, pseudocode, code not provided“AlphaFold 3 will be available as a non-commercial usage only server at https://www.alphafoldserver.com, with restrictions on allowed ligands and covalent modifications. Pseudocode describing the algorithms is available in the Supplementary Information. Code is not provided.”code availabilityInspect claim & evidence ↗
- StatementStated limit: conformation coverage is limited“Conformation coverage is limited.”Fig. 5 caption, panel cInspect claim & evidence ↗
- StatementAlphaFold 3 described by its authors as a diffusion-based model of complexes“Here we describe our AlphaFold 3 model with a substantially updated diffusion-based architecture that is capable of predicting the joint structure of complexes including proteins, nucleic acids, small molecules, ions and modified residues.”abstractInspect claim & evidence ↗
- StatementStated limit: spurious structural order in disordered regions“the switch from the non-generative AF2 model to the diffusion-based AF3 model introduces the challenge of spurious structural order (hallucinations) in disordered regions”"Model limitations" sectionInspect claim & evidence ↗