Critical Assessment of Methods of Protein Structure Prediction (CASP) – Round XIV
Proteins 89(12), 1607–1617, 7 October 2021 (NIH author manuscript consulted). Publication date and issue month from the PMC author-manuscript header ("Proteins. 2021 Oct 7;89(12):1607–1617"; "Issue date 2021 Dec"). Submission and acceptance dates are not stated there. PMC's "Published in final edited form" line does not state the kind of the day date. The paper is the CASP organisers' overview of the round.
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- Critical Assessment of Methods of Protein Structure Prediction (CASP) – Round XIV Proteins: Structure, Function, and Bioinformatics (author manuscript in PubMed Central) · published 2021-10-07 · Retrieved for the candidate pack on 2026-10-30 (SHA-256 df99b254a35a7840ddee25447610b25ab4a93154355ed2a0ec6db9b25d10710d). NIH author manuscript (PMC8726744) of Proteins 89(12):1607–1617; the publisher version of record was not retrieved.
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- StatementThe CASP14 organisers' own characterisation of what the results represent“In this sense, the results represent a solution to the classical protein folding problem, at least for single proteins.”abstractInspect claim & evidence ↗
- StatementCASP14: about two thirds of 96 targets considered competitive with experiment in backbone accuracy“In CASP14, about 2/3 of the 96 targets reached GDT_TS values greater than that, and so are considered competitive with experiment in backbone accuracy.”section "Three-dimensional Protein Structure Modeling" (PMC author manuscript)Inspect claim & evidence ↗
- StatementCASP14: deep learning methods from one research group delivered structures rivalling experimental ones, as the organisers state“In the most recent experiment (CASP14) deep learning methods from one research group consistently delivered computed structures rivalling the corresponding experimental ones in accuracy.”abstractInspect claim & evidence ↗
- StatementCASP14: other groups also advanced, and AlphaFold2 did not submit server models“Although this outstanding performance is dominated by AlphaFold2 (group 427), the dashed black line in Figure 1 shows that other groups also advanced substantially from CASP13.”section on three-dimensional protein structure modelingInspect claim & evidence ↗
- StatementCASP14 participation and target numbers as stated by the organisers“tested 215 modeling methods and submitted over 67,000 predictions in six prediction categories”introductory section on CASP14 participationInspect claim & evidence ↗
- StatementCASP described by its organisers as a community experiment with blind testing and independent assessors“CASP is a community experiment to advance methods of computing three-dimensional protein structure from amino acid sequence. Core components are rigorous blind testing of methods and evaluation of the results by independent assessors.”abstractInspect claim & evidence ↗